Integrins are cell adhesion and signalling proteins crucial to a wide range of biological
functions. Effective marketed treatments have successfully targeted integrins αIIbβ3 …

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

There is a requirement for efficacious and safe medicines to treat diseases with high unmet
need. The resurgence in αv‐RGD integrin inhibitor drug discovery is poised to contribute to …

Cancer stem cells (CSCs) in prostate cancer (CaP) are regarded as major contributors to
radioresistance due to complex mechanisms including enhanced DNA repair, increased …

Antibodies have proven their high value in antitumor therapy over the last two decades.
They are currently being used as the first-choice to treat some of the most frequent …

Sepsis is a life-threatening syndrome caused by a pathological host response to an infection
that eventually, if uncontrolled, leads to septic shock and ultimately, death. In sepsis, a …

Integrins are cell adhesion receptors predominantly important during normal and tumor
angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg …

The integrins are a family of 24 heterodimeric transmembrane cell surface receptors.
Involvement in cell attachment to the extracellular matrix, motility, and proliferation identifies …

Background Intetumumab is a fully human mAb with antiangiogenic, antitumor properties
which has shown potential therapeutic effect in castration-resistant prostate cancer (CRPC) …

Prostate cancer is the third leading cause of male cancer deaths in the developed world.
The current lack of highly specific detection methods and efficient therapeutic agents for …