Role of macrophages in pulmonary arterial hypertension

MQ Zhang, CC Wang, XB Pang, JZ Shi, HR Li… - Frontiers in …, 2023 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary vascular disease
characterized by progressive pulmonary artery pressure elevation, increased pulmonary …

Transcription factors and potential therapeutic targets for pulmonary hypertension

L Yang, N Wan, F Gong, X Wang, L Feng… - Frontiers in Cell and …, 2023 - frontiersin.org
Pulmonary hypertension (PH) is a refractory and fatal disease characterized by excessive
pulmonary arterial cell remodeling. Uncontrolled proliferation and hypertrophy of pulmonary …

Human umbilical cord mesenchymal stromal cell-derived exosomes alleviate hypoxia-induced pulmonary arterial hypertension in mice via macrophages

H Liu, Q Zhang, C Liu, Y Zhang, Y Wang, P Huang… - Stem Cells, 2024 - academic.oup.com
Pulmonary hypertension (PH) is an intractable, severe, and progressive cardiopulmonary
disease. Recent findings suggest that human umbilical cord mesenchymal stromal cells …

Therapeutic potential of natural flavonoids in pulmonary arterial hypertension: A review

J Zhang, M Shao, M Wang - Phytomedicine, 2024 - Elsevier
Background Pulmonary arterial hypertension (PAH) is a fatal disease caused by pulmonary
vascular remodeling, with a high incidence and mortality. At present, many clinical drugs for …

[HTML][HTML] Pyroptosis, apoptosis, necroptosis and endoplasmic reticulum stress in pulmonary hypertension

Q Yan, S Liu, Y Sun, C Chen, Y Yang, S Yang… - Journal of Advanced …, 2023 - Elsevier
Background Pulmonary hypertension (PH) represents a progressive condition characterized
by the remodeling of pulmonary arteries, ultimately culminating in right heart failure and …

Myeloid-derived suppressor cells and pulmonary hypertension

H Zhang, QW Li, YY Li, X Tang, L Gu… - Frontiers in …, 2023 - frontiersin.org
Pulmonary hypertension (PH) is a chronic pulmonary vascular disorder characterized by an
increase in pulmonary vascular resistance and pulmonary arterial pressure. The detailed …

Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice

X Meng, L Du, S Xu, L Zhou, B Chen, Y Li… - International Journal of …, 2024 - nature.com
Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the
prevention and treatment of the disease. In the current study, we showed that experimental …

The role of inflammation in the cellular and molecular mechanisms of cardiopulmonary complications of sickle cell disease

OT Gbotosho, J Gollamudi, HI Hyacinth - Biomolecules, 2023 - mdpi.com
Cardiopulmonary complications remain the major cause of mortality despite newer therapies
and improvements in the lifespan of patients with sickle cell disease (SCD). Inflammation …

[HTML][HTML] Inhibiting IL-6 in medicine: a new twist to sustain inhibition of his cytokine tin the therapy of pulmonary arterial hypertension

E Gugliandolo, F Macrì, R Fusco, R Siracusa… - Pharmacological …, 2023 - Elsevier
Pulmonary arterial hypertension (PAH) is a chronic, progressive disease characterized by
an increase in blood pressure in the lungs' arteries. It can occur in a variety of species …

Bioinformatics analysis of the immune cell infiltration characteristics and correlation with crucial diagnostic markers in pulmonary arterial hypertension

G Lian, J You, W Lin, G Gao, C Xu, H Wang… - BMC Pulmonary …, 2023 - Springer
Background Pulmonary arterial hypertension (PAH) is a pathophysiological syndrome,
characterized by pulmonary vascular remodeling. Immunity and inflammation are …