Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Cancer is one of the most fatal diseases of recent times that causes several deaths every
year. The disease variations in different parts of the world, the impact of available medical …

The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target
was a major breakthrough for the treatment of highly aggressive HER2-positive breast …

Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second
most common cause of cancer deaths. Initial clinical presentation as metastatic CRC …

Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer
patients and conferred durable clinical benefits, including cure in a subset of patients …

Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …