Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling
pathway throughout systems and across species. PKA facilitates the actions of hormones …

Objectives: Pre-existing or new diabetes confers an adverse prognosis in people with Covid-
19. We reviewed the clinical literature on clinical outcomes in metformin-treated subjects …

The biguanide metformin has been used as first-line therapy in type 2 diabetes mellitus
(T2DM) treatment for several decades. In addition to its glucose-lowering properties and its …

Highlights•Tautomers significantly influence solid state properties of drugs and drug
delivery.•Many drugs exhibit tautomerism, the tautomers are important in drug action …

Herein we trace links between biochemical pathways, pathogenesis, and metabolic
diseases to set the stage for new therapeutic advances. Cellular and acellular …

Metformin is a widely prescribed medication for the treatment and management of type 2
diabetes. It belongs to a class of biguanides, which are characterized by a wide range of …

The prime purpose of this work is to prepare a novel kind of Pickering interfacial solid
catalysts for biodiesel production to meet the requirements of highly efficiency and …

Biguanides have attracted much attention a century ago and showed resurgent interest in
recent years after a long period of dormancy. They constitute an important class of …

Cancer represents the main cause of death worldwide. Thyroid cancer (TC) shows an
overall good rate of survival, however there is a percentage of patients that do not respond …