The treatment of Candida infective endocarditis generally involves infected valve removal
accompanied by antifungal therapy with amphotericin B or a lipid-based derivative, with or …

Recent observations demonstrated that fluconazole plus cyclosporine (Cy) synergistically
killed Candida albicans in vitro. This combination was tested in rats with C. albicans …

Fungal endocarditis in premature infants has rarely been reported; only 16 cases have been
described. We present a fatal case of endocarditis due to Candida albicans in a patient …

Although there are an increasing number of new antifungal agents available, the morbidity
and mortality due to invasive mycoses remain high. The high rates of polyene toxicities and …

We compared the efficacies of fluconazole (Flu), amphotericin B (AmB), and 5-fluorocytosine
(5FC) monotherapies with the combination of Flu plus 5FC and Flu plus AmB in a rabbit …

The combination of fluconazole (FLC) and cyclosporine (CY) is fungicidal in FLC-
susceptible C. albicans (O. Marchetti, P. Moreillon, MP Glauser, J. Bille, and D. Sanglard …

Thrombin-induced platelet microbicidal protein (tPMP) exerts potent in vitro microbicidal
activity against pathogens commonly found in the bloodstream, including Staphylococcus …

To study the development and potential mechanisms of antifungal resistance in relation to
antifungal exposure, reversible fluconazole resistance was examined in vitro. Candida …

In vitro time-kill studies and a rabbit model of endocarditis and pyelonephritis were used to
define the impact that the order of exposure of Candida albicans to fluconazole (FLC) and …

We conducted steady-state pharmacokinetic studies with high-dose fluconazole with rabbits
and human volunteers. We then derived mathematical equations that predict the doses of …