Withania somnifera (L.) Dunal: Phytochemistry, structure-activity relationship, and anticancer potential

D Tewari, V Chander, A Dhyani, S Sahu, P Gupta… - Phytomedicine, 2022 - Elsevier
Background Ayurveda is a highly recognized, well-documented, and well-accepted
traditional medicine system. This system utilizes many natural products in various forms for …

Withania somnifera: Progress towards a Pharmaceutical Agent for Immunomodulation and Cancer Therapeutics

VK Kashyap, G Peasah-Darkwah, A Dhasmana… - Pharmaceutics, 2022 - mdpi.com
Chemotherapy is one of the prime treatment options for cancer. However, the key issues
with traditional chemotherapy are recurrence of cancer, development of resistance to …

[HTML][HTML] High-throughput screening of ancient forest plant extracts shows cytotoxicity towards triple-negative breast cancer

Y Li, NL Ma, H Chen, J Zhong, D Zhang, W Peng… - Environment …, 2023 - Elsevier
Abstract According to the World Health Organization, women's breast cancer is among the
most common cancers with 7.8 million diagnosed cases during 2016–2020 and …

Withania somnifera (L.) Dunal: A potential therapeutic adjuvant in cancer

A Saggam, G Tillu, S Dixit, P Chavan-Gautam… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Withania somnifera (L.) Dunal (WS) is one of the
moststudied Rasayana botanicals used in Ayurveda practice for its immunomodulatory, anti …

[HTML][HTML] Implications of Withaferin-A for triple-negative breast cancer chemoprevention

H Mallipeddi, A Thyagarajan, RP Sahu - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Triple-negative breast cancer (TNBC) accounts for about 15% of all breast cancer cases,
and unlike other malignancies, it lacks definite prognostic markers. While improved survival …

Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha)

V Mehta, H Chander, A Munshi - Nutrition and Cancer, 2021 - Taylor & Francis
Increasing herbal formulations have been used to treat several diseases including cancer.
W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested …

Withania somnifera modulates radiation-induced generation of lung cancer stem cells via restraining the hedgehog signaling factors

EM Moustafa, HS Abdel Salam… - Dose-Response, 2022 - journals.sagepub.com
Cancer stem cells (CSCs) are implicated in the genesis, development, and recurrence of
lung cancer (LC) with great resistance to radiation and chemotherapy. The aim of this study …

Keeping abreast about Ashwagandha in breast cancer

R Vashi, BM Patel, RK Goyal - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Ashwagandha has been used as an ayurvedic medicine
in the form of 'Rasayana'(as a tonic) even before 3000 BCE in India. As per Ayurveda, it has …

Cytoplasmic colocalization of RXRα and PPARγ as an independent negative prognosticator for breast cancer patients

W Shao, MB Köpke, T Vilsmaier, A Zati Zehni… - Cells, 2022 - mdpi.com
Retinoid X receptor α (RXRα) is a nuclear receptor (NR) which functions as the primary
heterodimeric partner of other NRs including the peroxisome proliferator-activated receptor γ …

[HTML][HTML] Characterization and anticancer potential of Withania somnifera fruit bioactives (a native species to Pakistan) using gas chromatography-mass spectrometer …

T Qudsia, M Tahir, A Sibtain, A Farooq… - Journal of Traditional …, 2022 - ncbi.nlm.nih.gov
AIM: This comprehensive study is aimed to characterize phytochemicals in fruit of W.
somnifera and tested for in vitro anticancer potential to find out active candidate in disease …