Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

Mechanosensitive PIEZO channels constitute potential pharmacological targets for multiple
clinical conditions, spurring the search for potent chemical PIEZO modulators. Among them …

Mechanical forces are an inherent element in the world around us. The effects of their action
can be observed both on the macro and molecular levels. They can also play a prominent …

Mechanical features of cancer cells emerge as a distinct trait during development and
progression of solid tumors. Herein, we discuss recent key findings regarding the impact of …

Within the complex tumor microenvironment, cells experience mechanical cues—such as
extracellular matrix stiffening and elevation of solid stress, interstitial fluid pressure, and fluid …

Physical cues have emerged as critical influencers of cell function during physiological
processes, like development and organogenesis, and throughout pathological …

Cellular unjamming is the collective fluidization of cell motion and has been linked to many
biological processes, including development, wound repair, and tumor growth. In tumor …

Simple Summary Tumor cells obtain various unique characteristics, which known as
hallmarks of cancers, including sustained proliferative signaling, apoptosis resistance, and …

Cancer invasion through the surrounding epithelium and extracellular matrix (ECM) is the
one of the main characteristics of cancer progression. While significant effort has been made …