Hypoxia: a double-edged sword in cancer therapy
H Manoochehri Khoshinani, S Afshar… - Cancer …, 2016 - Taylor & Francis
Hypoxia is a common feature of malignant tumors. There is an interactive connection
between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis …
between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis …
Significance of nitroimidazole compounds and hypoxia‐inducible factor‐1 for imaging tumor hypoxia
S Kizaka‐Kondoh, H Konse‐Nagasawa - Cancer science, 2009 - Wiley Online Library
A tumor‐specific microenvironment is characterized by hypoxia, in which oxygen tension is
considerably lower than in normal tissues. The hypoxic status of various solid tumors has …
considerably lower than in normal tissues. The hypoxic status of various solid tumors has …
[HTML][HTML] Oxygen imaging of living cells and tissues using luminescent molecular probes
T Yoshihara, Y Hirakawa, M Hosaka… - … of Photochemistry and …, 2017 - Elsevier
Oxygen imaging of biological cells and tissues is becoming increasingly important in cell
biology and in the pathophysiology of various hypoxia-related diseases. The optical oxygen …
biology and in the pathophysiology of various hypoxia-related diseases. The optical oxygen …
Significance of HIF-1-active cells in angiogenesis and radioresistance
H Harada, S Kizaka-Kondoh, G Li, S Itasaka, K Shibuya… - Oncogene, 2007 - nature.com
Human solid tumors contain hypoxic regions that have considerably lower oxygen tension
than the normal tissues. Hypoxia offers resistance to radiotherapy and anticancer …
than the normal tissues. Hypoxia offers resistance to radiotherapy and anticancer …
Tumor hypoxia imaging
There is a need to measure tumor hypoxia in assessing the aggressiveness of tumor and
predicting the outcome of therapy. A number of invasive and noninvasive techniques have …
predicting the outcome of therapy. A number of invasive and noninvasive techniques have …
The HIF-1-active microenvironment: an environmental target for cancer therapy
S Kizaka-Kondoh, S Tanaka, H Harada… - Advanced drug delivery …, 2009 - Elsevier
Solid tumors possess unique microenvironments that are exposed to chronic hypoxic
conditions, so-called tumor hypoxia. Although more than half a century has passed since it …
conditions, so-called tumor hypoxia. Although more than half a century has passed since it …
Selective killing of hypoxia-inducible factor-1–active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer
S Kizaka-Kondoh, S Itasaka, L Zeng, S Tanaka… - Clinical Cancer …, 2009 - AACR
Purpose: Pancreatic cancer is characterized by intratumoral hypoxia, early and aggressive
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …
[HTML][HTML] SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization
T Suwa, M Kobayashi, Y Shirai, JM Nam, Y Tabuchi… - JCI insight, 2021 - ncbi.nlm.nih.gov
Hypoxia is associated with tumor radioresistance; therefore, a predictive marker for tumor
hypoxia and a rational target to overcome it have been sought to realize personalized …
hypoxia and a rational target to overcome it have been sought to realize personalized …
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy
H Harada, S Itasaka, Y Zhu, L Zeng, X Xie… - British journal of …, 2009 - nature.com
Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …
In vivo noninvasive preclinical tumor hypoxia imaging methods: a review
RA D'Alonzo, S Gill, P Rowshanfarzad… - … Journal of Radiation …, 2021 - Taylor & Francis
Tumors exhibit areas of decreased oxygenation due to malformed blood vessels. This low
oxygen concentration decreases the effectiveness of radiation therapy, and the resulting …
oxygen concentration decreases the effectiveness of radiation therapy, and the resulting …