Summary Abstract Lacidipine (Caldine®, Lacimen®, Lacipil®, Midotens®, Motens®) is a
once-daily, orally-administered, lipophilic dihydropyridine calcium antagonist with an …

Increasing knowledge of the role of nitric oxide (NO) in physiology and disease has
stimulated efforts to target the NO pathway pharmacologically. These therapeutic strategies …

A large body of evidence indicates that patients with essential hypertension, and even more
those with complicated hypertension, are characterized by endothelial dysfunction …

The advances made in vascular biology in the last 25 years have considerably changed the
perception that one could have of the endothelial cells. Once considered as a diffusion …

Recent studies suggest that hypertension associated with low renin status and
hyperaldosteronism is associated with increased risk for end-organ damage and …

Objectives. Endothelin‐1 (ET‐1) and angiotensin II may contribute to endothelial
dysfunction, which is associated with increased risk of events in patients with coronary artery …

В обзоре рассмотрена эндотелиальная функция/дисфункция в обеспечении ряда
физиологических и патофизиологических процессов, а также функционирования …

The aim of the study was to investigate the effect of therapy by perindopril or telmisartan on
endothelial/platelet function and on coagulation/fibrinolysis in 20 and 16 hypertensive …

Increased expression/activity of matrix metalloproteinases (MMPs), especially MMP-2, plays
a role in the vascular alterations induced by hypertension, and increased oxidative stress is …

Endothelial function is impaired in hypertension and ageing and this may be associated with
an increase in cardiovascular disease. Several clinical studies have shown that blocking the …