The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …

The plasma coagulation system in mammalian blood consists of a cascade of enzyme
activation events in which serine proteases activate the proteins (proenzymes and …

Background Hereditary angioedema is a rare and potentially life-threatening genetic
disease that is associated with kallikrein–kinin system dysregulation. Garadacimab …

The contact system is a plasma protease cascade initiated by factor XII (FXII) that activates
the proinflammatory kallikrein‐kinin system and the procoagulant intrinsic coagulation …

The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly
the longest-living mammal. These animals should possess protective molecular adaptations …

Background The interaction of coagulation factors has been shown to go beyond their
traditional roles in hemostasis and to affect the development of inflammatory diseases. Key …

Inflammation is a protective response of the body potentially caused by microbial, viral, or
fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of …

Currently used anticoagulants prevent thrombosis but increase bleeding. We show an
anticoagulation therapy without bleeding risk based on a plasma protease factor XII function …

Platelets play a central role in primary hemostasis by forming aggregates that plug holes in
injured vessels. Half a century ago, detailed studies of the microvasculature by electron …

Excessive blood loss is one of the leading causes of death in trauma, and developing
injectable and antibacterial shape-memory hemostatic materials with high blood absorption …