Infectious Diseases Society of America 2023 guidance on the treatment of antimicrobial resistant gram-negative infections

PD Tamma, SL Aitken, RA Bonomo… - Clinical Infectious …, 2023 - academic.oup.com
Abstract Background The Infectious Diseases Society of America is committed to providing
up-to-date guidance on the treatment of antimicrobial-resistant infections. This guidance …

Cefiderocol: systematic review of mechanisms of resistance, heteroresistance and in vivo emergence of resistance

S Karakonstantis, M Rousaki, EI Kritsotakis - Antibiotics, 2022 - mdpi.com
Cefiderocol appears promising, as it can overcome most β-lactam resistance mechanisms
(including β-lactamases, porin mutations, and efflux pumps). Resistance is uncommon …

Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus …

KS Kaye, AF Shorr, RG Wunderink, B Du… - The Lancet Infectious …, 2023 - thelancet.com
Background An urgent need exists for antibiotics to treat infections caused by carbapenem-
resistant Acinetobacter baumannii–calcoaceticus complex (ABC). Sulbactam–durlobactam …

Navigating Available Treatment Options for Carbapenem-Resistant Acinetobacter baumannii-calcoaceticus Complex Infections

RK Shields, DL Paterson… - Clinical Infectious …, 2023 - academic.oup.com
Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of
the top-priority pathogens for new antibiotic development. Unlike other antibiotic-resistant …

Acinetobacter baumannii in the critically ill: complex infections get complicated

I Cavallo, A Oliva, R Pages, F Sivori, M Truglio… - Frontiers in …, 2023 - frontiersin.org
Acinetobacter baumannii is increasingly associated with various epidemics, representing a
serious concern due to the broad level of antimicrobial resistance and clinical …

[HTML][HTML] Diagnosis and management of infections caused by multidrug-resistant bacteria: guideline endorsed by the Italian Society of Infection and Tropical Diseases …

G Tiseo, G Brigante, DR Giacobbe, AE Maraolo… - International Journal of …, 2022 - Elsevier
Management of patients with infections caused by multidrug-resistant organisms is
challenging and requires a multidisciplinary approach to achieve successful clinical …

Mortality attributable to bloodstream infections caused by different carbapenem-resistant Gram-negative bacilli: results from a nationwide study in Italy (ALARICO …

M Falcone, G Tiseo, S Carbonara… - Clinical Infectious …, 2023 - academic.oup.com
Background Our aim was to analyze mortality attributable to carbapenem-resistant (CR)
gram-negative bacilli (GNB) in patients with bloodstream infections (BSIs). Methods …

[HTML][HTML] Efficacy of cefiderocol-vs colistin-containing regimen for treatment of bacteraemic ventilator-associated pneumonia caused by carbapenem-resistant …

A Russo, A Bruni, S Gullì, C Borrazzo, A Quirino… - International journal of …, 2023 - Elsevier
Introduction Ventilator-associated pneumonia (VAP) caused by carbapenem-resistant
Acinetobacter baumannii (CRAB) in patients hospitalized in intensive care units (ICUs) is an …

Jumping into the future: overcoming pharmacokinetic/pharmacodynamic hurdles to optimize the treatment of severe difficult to treat-Gram-negative infections with …

M Gatti, F Pea - Expert Review of Anti-infective Therapy, 2023 - Taylor & Francis
Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR)
Gram-negative infections currently represents an unmet clinical need. Areas covered This …

New antibiotics for Gram-negative pneumonia

M Bassetti, F Magnè, DR Giacobbe… - European Respiratory …, 2022 - Eur Respiratory Soc
Pneumonia is frequently encountered in clinical practice, and Gram-negative bacilli
constitute a significant proportion of its aetiology, especially when it is acquired in a hospital …