The mechanism of maladaptive chronic stress response involves altered phosphorylation of
the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic …

Rationale Inflammation plays a key role in the pathogenesis of major depressive disorder
(MDD) for a subset of depressed individuals. One of the possible routes by which cytokines …

Inflammation plays a critical role in pathogenesis of depression and can affect the
hypothalamic-pituitary-adrenal axis activity. Accordingly, in this study we investigated the …

Objectives. To develop a structural equation model of negative affectivity (NA) that involves
interaction of glucocorticoid receptor (GR) signaling, personality dimensions and recent …

Substance use disorders (SUDs) are a devastating and under-treated public health concern
worldwide, and are often conceptualized as chronic stress disorders (Koob et al., 2014) …

Предъявление стрессовых событий вызывает активацию гипоталамо-гипофизарно-
надпочечниковой системы, приводя к повышенному уровню глюкокортикоидных …

Caffeic acid phenethyl ester (CAPE) is an active component of propolis that has a variety of
potential pharmacological effects. Although we previously demonstrated that propolis has …

Depression is associated with immune dysregulation and the aberrant activity of the
hypothalamic-pituitaryadrenal (HPA) axis. However, the neurobiological molecular …

Current first-line treatments for depression, namely monoamine-based drugs such as SSRIs,
take weeks to show any clinical effects, and they are only effective in 60-70% of patients …