The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
The ins and outs of the striatum: role in drug addiction
Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …
intake, high motivation to obtain the drug, and a persistent craving for the drug …
Animal models of drug relapse and craving after voluntary abstinence: a review
Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …
several decades, this clinical scenario has been studied at the preclinical level using classic …
Stress-induced reinstatement of drug seeking: 20 years of progress
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
Cortico-striatal-thalamic loop circuits of the orbitofrontal cortex: promising therapeutic targets in psychiatric illness
Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …
human behaviors such as evaluation, affect regulation and reward-based decision-making …
Time to connect: bringing social context into addiction neuroscience
M Heilig, DH Epstein, MA Nader… - Evaluating the Brain …, 2022 - taylorfrancis.com
Research on the neural substrates of drug reward, withdrawal and relapse has yet to be
translated into significant advances in the treatment of addiction. One potential reason is that …
translated into significant advances in the treatment of addiction. One potential reason is that …
Long-term depression in the CNS
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a
process that may be involved in learning and memory and in various pathological …
process that may be involved in learning and memory and in various pathological …
[HTML][HTML] Reward processing by the opioid system in the brain
J Le Merrer, JAJ Becker, K Befort… - Physiological …, 2009 - journals.physiology.org
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …
The glutamate homeostasis hypothesis of addiction
PW Kalivas - Nature reviews neuroscience, 2009 - nature.com
Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …
Understanding addiction using animal models
Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …
extraordinary global economic impact. Despite decades of research, the options available to …