The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …

Inducing antiretroviral therapy (ART)-free virological control is a critical step toward a human
immunodeficiency virus type 1 (HIV-1) cure. In this phase 2a, placebo-controlled, double …

Spontaneous transcription and translation of HIV can persist during suppressive
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …

Successful approaches for eradication or cure of HIV-1 infection are likely to include
immunological mechanisms, but remarkably little is known about how human immune …

The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1)
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …

Abstract Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …

The development of latency reversing agents that potently reactivate HIV without inducing
global T cell activation would benefit the field of HIV reservoir research and could pave the …

BACKGROUND HIV-1–infected CD4+ T cells contribute to latent reservoir persistence by
proliferating while avoiding immune recognition. Integration features of intact proviruses in …

Objectives: People with HIV-1 (PWH) on effective antiretroviral therapy (ART) continue to
exhibit chronic systemic inflammation, immune activation, and persistent elevations in …

The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably
integrated provirus. Previous studies characterizing the proviral landscape, which have …