Vascular disease is a progressive inflammatory condition fuelled by an unhealthy lifestyle of
physical inactivity, cholesterol-rich diet, and smoking. Together with endogenous factors …

Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), polycythemia
vera, essential thrombocythemia, and primary myelofibrosis, are hematopoietic stem cell …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

Older patients are underrepresented in prospective studies and randomized clinical trials of
acute coronary syndromes (ACS). Over the last decade, a few specific trials have been …

Significance: Both incidence and mortality rates of sepsis significantly increase with
advanced age, and the majority of sepsis patients are late middle-aged or older. With the …

Elderly-onset rheumatoid arthritis (EORA) is a distinct clinical entity defined as the onset of
rheumatoid arthritis (RA) in individuals aged over 60 years. EORA presents unique clinical …

Purpose of the review The study of platelets in the context of neurodegenerative diseases is
intensifying, and increasing evidence suggests that platelets may play an important role in …

Platelets control hemostasis and play a key role in inflammation and immunity. However,
platelet function may change during aging, and a role for these versatile cells in many age …

Background: Rheumatoid arthritis (RA) occurs more often in elderly individuals. Elderly
onset RA (EORA)(onset> 60 years) encompasses a specific subset of patients if compared …

Neurodegenerative disorders (NDDs) are complex, multifactorial disorders with significant
social and economic impact in today's society. NDDs are predicted to become the second …