Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Peroxisomes are dynamic organelles that play an essential role in a variety of cellular
catabolic and anabolic metabolic pathways, including fatty acid alpha-and beta-oxidation …

Defects in PEX genes impair peroxisome assembly and multiple metabolic pathways
confined to this organelle, thus providing the biochemical and molecular bases of the …

Human peroxisome biogenesis disorders (PBDs) are a heterogeneous group of autosomal
recessive disorders comprised of two clinically distinct subtypes: the Zellweger syndrome …

Translocation of proteins across membranes of the endoplasmic reticulum, mitochondrion,
and chloroplast has been shown to be mediated by targeting signals present in the …

Zellweger syndrome, neonatal adrenoleukodystrophy, infantile Refsum disease and
rhizomelic chondrodysplasia punctata are progressive disorders characterized by loss of …

Peroxisomes are components of virtually all eukaryotic cells. While much is known about
peroxisomal matrix protein import, our understanding of how peroxisomal membrane …

PEX19 is a chaperone and import receptor for newly synthesized, class I peroxisomal
membrane proteins (PMPs). PEX19 binds these PMPs in the cytoplasm and delivers them to …

▪ Abstract Fifteen years ago, we had a model of peroxisome biogenesis that involved growth
and division of preexisting peroxisomes. Today, thanks to genetically tractable model …

Peroxisomes transport folded and oligomeric proteins across their membrane. Two cytosolic
import receptors, Pex5p and Pex7p, along with approximately 12 membrane-bound …