Clinical implementation of pharmacogenomics for personalized precision medicine: barriers and solutions

ME Klein, MM Parvez, JG Shin - Journal of pharmaceutical sciences, 2017 - Elsevier
Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which
improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based …

What are the barriers and enablers to the implementation of pharmacogenetic testing in mental health care settings?

A Jameson, B Fylan, GC Bristow, GS Sagoo… - Frontiers in …, 2021 - frontiersin.org
In psychiatry, the selection of antipsychotics and antidepressants is generally led by a trial-
and-error approach. The prescribing of these medications is complicated by sub-optimal …

Primary care physicians' knowledge of and experience with pharmacogenetic testing

SB Haga, W Burke, GS Ginsburg, R Mills… - Clinical …, 2012 - Wiley Online Library
It is anticipated that as the range of drugs for which pharmacogenetic testing becomes
available expands, primary care physicians (PCPs) will become major users of these tests …

[HTML][HTML] Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions

S Reisberg, K Krebs, M Lepamets, M Kals, R Mägi… - Genetics in …, 2019 - Elsevier
Purpose Biomedical databases combining electronic medical records and phenotypic and
genomic data constitute a powerful resource for the personalization of treatment. To …

Inconsistency in race and ethnic classification in pharmacogenetics studies and its potential clinical implications

F Zhang, J Finkelstein - Pharmacogenomics and personalized …, 2019 - Taylor & Francis
Introduction Racial and ethnic categories are frequently used in pharmacogenetics literature
to stratify patients; however, these categories can be inconsistent across different studies. To …

Pharmacogenomics in clinical trials: an overview

R Nogueiras-Álvarez - Frontiers in Pharmacology, 2023 - frontiersin.org
With the trend towards promoting personalised medicine (PM), the application of
pharmacogenetics and pharmacogenomics (PGx) is of growing importance. For the …

An index of barriers for the implementation of personalised medicine and pharmacogenomics in Europe

D Horgan, M Jansen, L Leyens, JA Lal… - Public health …, 2014 - karger.com
Background: Personalised medicine (PM) is an innovative way to produce better patient
outcomes by using an individualised or stratified approach to disease and treatment rather …

[HTML][HTML] Pharmacogenetics: an important part of drug development with a focus on its application

JT Oates, D Lopez - International journal of biomedical …, 2018 - ncbi.nlm.nih.gov
Since the human genome project in 2003, the view of personalized medicine to improve
diagnosis and cure diseases at the molecular level became more real. Sequencing the …

Nanomedicine and personalized medicine toward the application of pharmacotyping in clinical practice to improve drug-delivery outcomes

IS Vizirianakis - Nanomedicine: Nanotechnology, Biology and Medicine, 2011 - Elsevier
Recent technological advances in nanomedicine and nanotechnology in parallel with
knowledge accumulated from the clinical translation of disease-and drug-related genomic …

Antimicrobial treatment imprecision: an outcome-based model to close the data-to-action loop

A Howard, N Reza, S Aston, B Woods… - The Lancet Infectious …, 2024 - thelancet.com
Health-care systems, food supply chains, and society in general are threatened by the
inexorable rise of antimicrobial resistance. This threat is driven by many factors, one of …