Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is highly aggressive
and hypoxic compared with other subtypes. The role of hypoxia inducible factor 1α (HIF-1α) …

Breast cancer is the most common cancer in women worldwide with increasing incidence.
Significant therapeutics advances in the field of breast cancer have resulted in a growing …

Hypoxia is caused by a cancer-promoting milieu characterized by persistent inflammation.
NF-κB and HIF-1α are critical participants in this transition. Tumor development and …

It is well known that solid hypoxic tumour cells oxidise glucose through glycolysis, and the
end product of this pathway is fermented into lactate which accumulates in the tumour …

Breast cancer (BC) is the most common cancer type among women with a distinct clinical
presentation, but the survival rate remains moderate despite advances in multimodal …

Many energy metabolism pathways exist in cancer, including glycolysis, amino acid
metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate …

Background Acute myeloid leukaemia (AML) is a deadly disease characterised by the
uncontrolled proliferation of immature myeloid cells within the bone marrow. Altered …

Hypoxia-inducible factor-1 (HIF-1) is a key regulator for balancing oxygen in the cells. It is a
transcription factor that regulates the expression of target genes involved in oxygen …

Tendinopathy is a debilitating condition marked by degenerative changes in the tendons. Its
complex pathophysiology involves intrinsic, extrinsic, and physiological factors. While its …

Poxviruses are double-stranded DNA viruses that infect insects and a variety of vertebrate
species. The large genomes of poxviruses contain numerous genes that allow these viruses …