The fight against neurodegenerative diseases, Alzheimer disease and Parkinson's disease
(PD), is a challenge of the 21st century. The low efficacy of treating patients is due to the late …

Though a multi-facetted disorder, Parkinson's disease is prototypically characterized by
neurodegeneration of nigrostriatal dopaminergic neurons of the substantia nigra pars …

Establishing the molecular diversity of cell types is crucial for the study of the nervous
system. We compiled a cross-laboratory database of mouse brain cell type-specific …

Since the late 80s it has been repeatedly shown that besides dopaminergic neurons, the
brain contains so-called monoenzymatic neurons possessing one of the enzymes of …

The human anterior cingulate and frontoinsular cortices are distinguished by 2 unique Layer
5 neuronal morphotypes, the von Economo neurons (VENs) and fork cells, whose biological …

Since the discovery of striatal neurons expressing dopamine-synthesizing enzymes,
researchers have attempted to identify their phenotype and functional significance. In this …

We have recently shown that the periventricular nucleus (PeVN) of adult rats is a “mixed
dopaminergic (DAergic) center” containing three thousand neurons: DAergic neurons and …

Besides dopaminergic (DA-ergic) neurons having all enzymes of DA synthesis, tyrosine
hydroxylase (TH) and aromatic l-amino acid decarboxylase (AADC),“monoenzymatic” …

Caffeine is a methylxanthine consumed in different contexts to potentiate alertness and
reduce fatigue. However, caffeine can induce anxiety at high doses. Caffeine is also a minor …

Since the 1980s, the concept of dopamine-rich brain centers as clusters of only
dopaminergic neurons has been fundamentally revised. It has been shown that, in addition …