Notable progress in basic, translational and clinical nephrology research has been made
over the past five decades. Nonetheless, many challenges remain, including obstacles to …

In this state-of-the-art review we detail the journey of xenotransplantation from its infancy,
detailing one of the first published cases and the subsequent journey the field took in its …

Natural killer (NK) cells play an important role in immune rejection in solid organ
transplantation. To mitigate human NK cell activation in xenotransplantation, introducing …

Cationic antimicrobial peptides are molecules with potential applications for treating
infections due to their antimicrobial and immunomodulatory properties. The aim of this work …

Background Given their physiological similarities to humans, pigs are increasingly used as
model organisms in human-oriented biomedical studies. Additionally, their value to animal …

The incidence of diabetes mellitus (DM) is steadily increasing annually, with 537 million
diabetic patients as of 2021. Restoring diminished β cell mass or impaired islet function is …

The purpose of this study was to develop a monoclonal antibody (mAb) that can identify
porcine dendritic cells (DCs) that have differentiated from bone marrow progenitor cells …

There are critical shortages in donor organs available for transplantation in the United
States, with some racial and ethnic groups facing disparities in access. Xenotransplantation …

Transplantation remains the preferred treatment for end‐stage kidney disease but is critically
limited by the number of available organs. Xenografts from genetically modified pigs have …

Cationic antimicrobial peptides are molecules with potential applications for treating
infections due to their antimicrobial and immunomodulatory properties. The aim of this work …