Angiogenesis is an important component in the development of thyroid goitre. Vascular
endothelial growth factor (VEGF) represents a family of specific endothelial cell mitogens …

Continuing Medical Education examination CONTINUING MEDICAL EDUCATION
ARTICLECredit can now be obtained, free for a limited time, by reading the following review …

Synthetic glucocorticoids (GCs) potently inhibit the expression of pro-inflammatory genes
and are widely used in the treatment of inflammatory diseases. However, some patients are …

Background Asthma, a common chronic inflammatory disease, is treated with corticosteroid
in most cases, but corticosteroid resistance in severe asthma patients seriously impairs the …

Glucocorticoids are the mainstay of asthma management and effectively treat acute
exacerbations of asthma. However, a small subset of asthmatics, usually with severe …

Asthma represents a profound worldwide public health problem. The most effective anti-
asthmatic drugs currently available include inhaled β2-agonists and glucocorticoids and …

Background Patients with severe asthma appear relatively corticosteroid resistant.
Corticosteroid responsiveness is closely related to the degree of eosinophilic airway …

BACKGROUND: Leukotriene B4 (LTB4) is a potent inflammatory lipid mediator that binds to
LTB4 receptor 1 (BLT1). Ligation of BLT1 by LTB4 plays an important role in the recruitment …

Several factors impact the immune responses such as the chemical nature of antigens, the
physiologic and metabolic condition of the responsive cells, the site of antigen recognition …

The hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoid responses are
critical for survival from a number of bacterial, viral and toxic insults, demonstrated by the fact …