[HTML][HTML] Human engineered heart tissue models for disease modeling and drug discovery
The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
[HTML][HTML] Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
DM Zhang, R Navara, T Yin, J Szymanski… - Nature …, 2021 - nature.com
Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with
refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation …
refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation …
[HTML][HTML] Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes
Technical advances in generating and phenotyping cardiomyocytes from human pluripotent
stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to …
stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to …
Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia
G Campostrini, G Kosmidis… - Cardiovascular …, 2023 - academic.oup.com
Aims Human-induced pluripotent stem cell-cardiomyocytes (hiPSC-CMs) are widely used to
study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium …
study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium …
[HTML][HTML] Molecular pathology of sodium channel beta-subunit variants
P Angsutararux, W Zhu, TL Voelker… - Frontiers in …, 2021 - frontiersin.org
The voltage-gated Na+ channel regulates the initiation and propagation of the action
potential in excitable cells. The major cardiac isoform Na V 1.5, encoded by SCN5A …
potential in excitable cells. The major cardiac isoform Na V 1.5, encoded by SCN5A …
Mechanisms of noncovalent β subunit regulation of NaV channel gating
Voltage-gated Na+ (NaV) channels comprise a macromolecular complex whose
components tailor channel function. Key components are the non-covalently bound β1 and …
components tailor channel function. Key components are the non-covalently bound β1 and …
[HTML][HTML] Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of NaV1.5 sodium channels
J de la Roche, P Angsutararux, H Kempf, M Janan… - Scientific reports, 2019 - nature.com
Loss-of-function mutations of the SCN5A gene encoding for the sodium channel α-subunit
NaV1. 5 result in the autosomal dominant hereditary disease Brugada Syndrome (BrS) with …
NaV1. 5 result in the autosomal dominant hereditary disease Brugada Syndrome (BrS) with …
[HTML][HTML] The march of pluripotent stem cells in cardiovascular regenerative medicine
Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and
mortality. Heart failure remains a major contributor to this mortality. Despite major …
mortality. Heart failure remains a major contributor to this mortality. Despite major …
Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential
A van Mil, GM Balk, K Neef, JW Buikema… - Cardiovascular …, 2018 - academic.oup.com
In the past few years, the use of specific cell types derived from induced pluripotent stem
cells (iPSCs) has developed into a powerful approach to investigate the cellular …
cells (iPSCs) has developed into a powerful approach to investigate the cellular …
[HTML][HTML] The emergence of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as a platform to model arrhythmogenic diseases
M Pourrier, D Fedida - International journal of molecular sciences, 2020 - mdpi.com
There is a need for improved in vitro models of inherited cardiac diseases to better
understand basic cellular and molecular mechanisms and advance drug development. Most …
understand basic cellular and molecular mechanisms and advance drug development. Most …