[HTML][HTML] Inflammatory response in dry eye

T Yamaguchi - Investigative ophthalmology & visual science, 2018 - iovs.arvojournals.org
Purpose: Dry eye is a major ocular pathology worldwide. Although dry eye is a multifactorial
disease, recent studies have shown that chronic immunologic processes have a pivotal role …

Autoimmunity in dry eye disease–an updated review of evidence on effector and memory Th17 cells in disease pathogenicity

Y Chen, R Dana - Autoimmunity reviews, 2021 - Elsevier
Abstract The classic Th1/Th2 dogma has been significantly reshaped since the subsequent
introduction of several new T helper cell subsets, among which the most intensively …

Unveiling the power of gabapentin-loaded nanoceria with multiple therapeutic capabilities for the treatment of dry eye disease

CJ Yang, A Anand, CC Huang, JY Lai - ACS nano, 2023 - ACS Publications
Dry eye (DE) disease, which is primarily linked to aqueous deficiency, is an escalating
health issue worldwide, mainly due to the widespread use of electronic devices. The major …

[HTML][HTML] Randomised double-masked placebo-controlled trial of the cumulative treatment efficacy profile of intense pulsed light therapy for meibomian gland …

AL Xue, MTM Wang, SE Ormonde, JP Craig - The Ocular Surface, 2020 - Elsevier
Purpose To assess long-term cumulative treatment effects of intense pulsed light (IPL)
therapy in meibomian gland dysfunction (MGD). Methods Eighty-seven symptomatic …

Alterations in corneal nerves in different subtypes of dry eye disease: an in vivo confocal microscopy study

SM Cox, A Kheirkhah, S Aggarwal, F Abedi… - The Ocular Surface, 2021 - Elsevier
Purpose To evaluate corneal subbasal nerve alterations in evaporative and aqueous-
deficient dry eye disease (DED) as compared to controls. Methods In this retrospective …

[HTML][HTML] Mucoadhesive, antioxidant, and lubricant catechol-functionalized poly (phosphobetaine) as biomaterial nanotherapeutics for treating ocular dryness

HL Bui, YH Su, CJ Yang, CJ Huang, JY Lai - Journal of …, 2024 - Springer
Dry eye disease (DED) is associated with ocular hyperosmolarity and inflammation. The
marketed topical eye drops for DED treatment often lack bioavailability and precorneal …

[HTML][HTML] Risk factors for fluctuations in corneal endothelial cell density

R Vaiciuliene, N Rylskyte… - Experimental and …, 2022 - spandidos-publications.com
The cornea is a transparent, avascular and abundantly innervated tissue through which light
rays are transmitted to the retina. The innermost layer of the cornea, also known as the …

[HTML][HTML] Sensory neurons directly promote angiogenesis in response to inflammation via substance P signaling

L Liu, R Dana, J Yin - FASEB journal: official publication of the …, 2020 - ncbi.nlm.nih.gov
Blood vessels and nerves travel together to supply most tissues in the body. However, there
is a knowledge gap in the mechanisms underlying the direct regulation of angiogenesis by …

[HTML][HTML] Alteration of corneal biomechanical properties in patients with dry eye disease

V Satitpitakul, P Taweekitikul, V Puangsricharern… - Plos one, 2021 - journals.plos.org
Purpose To evaluate the association between symptoms and signs of dry eye diseases
(DED) with corneal biomechanical parameters. Methods This cross-sectional study enrolled …

The impact of dry eye disease on corneal nerve parameters: A systematic review and meta‐analysis

JCB Chiang, V Tran… - … and Physiological Optics, 2023 - Wiley Online Library
Purpose Dry eye disease (DED) is a growing global health problem with a significant impact
on the quality of life of patients. While neurosensory abnormalities have been recognised as …