Infections of antibiotic-resistant pathogens pose an ever-increasing threat to mankind. The
investigation of novel approaches for tackling the antimicrobial resistance crisis must be part …

Relebactam (formerly known as MK-7655) is a non-β-lactam, bicyclic diazabicyclooctane, β-
lactamase inhibitor that is structurally related to avibactam, differing by the addition of a …

The causes of antibiotic resistance are complex and include human behaviour at many
levels of society; the consequences affect everybody in the world. Similarities with climate …

There is growing global recognition that the continued emergence of multidrug-resistant
bacteria poses a serious threat to human health. Action plans released by the World Health …

Rooted in the mechanism of action of antibiotics and subject to bacterial evolution, antibiotic
resistance is difficult and perhaps impossible to overcome. Nevertheless, strategies can be …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

The emergence and spread of carbapenem-resistant Gram-negative pathogens is a global
public health problem. The acquisition of metallo-β-lactamases (MBLs) such as NDM-1 is a …

Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a
growing concern due to limited therapeutic options. Gram-negative bacteria, specifically …

The growing number of bacterial pathogens that are resistant to numerous antibiotics is a
cause for concern around the globe. There have been no new broad‐spectrum antibiotics …

The continued emergence of multi-drug-resistant bacteria is a major public health concern.
The identification and development of new antibiotics, especially those with new modes of …