[HTML][HTML] Alzheimer's disease as a viral disease: Revisiting the infectious hypothesis

F Bruno, P Abondio, R Bruno, L Ceraudo… - Ageing research …, 2023 - Elsevier
Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people.
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …

[HTML][HTML] Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories

S Hassamal - Frontiers in psychiatry, 2023 - frontiersin.org
In a subset of patients, chronic exposure to stress is an etiological risk factor for
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …

EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling

Y Luo, T Ali, Z Liu, R Gao, A Li, C Yang, L Ling, L He… - Life Sciences, 2023 - Elsevier
Aims Erythropoietin (EPO) is a glycoprotein cytokine that exerts therapeutic potential on
neurological disorders by promoting neurogenesis and angiogenesis. However, its role as …

Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents

T Mokhtari - Phytotherapy Research, 2022 - Wiley Online Library
Major depressive disorder (MDD) is a life‐threatening disease that presents several
characteristics. The pathogenesis of depression still remains poorly understood. Moreover …

[HTML][HTML] Microglial responses to stress-induced depression: causes and consequences

R Afridi, K Suk - Cells, 2023 - mdpi.com
Chronic stress is a major risk factor for various psychiatric diseases, including depression; it
triggers various cellular and structural changes, resulting in the alteration of neurocircuitry …

Canagliflozin attenuates chronic unpredictable mild stress induced neuroinflammation via modulating AMPK/mTOR autophagic signaling

LH Khedr, RM Eladawy, NN Nassar, MAE Saad - Neuropharmacology, 2023 - Elsevier
Although vast progress has been made to understand the pathogenesis of depression,
existing antidepressant remedies, with several adverse effects, are not fully adequate …

Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model

H Cao, D Yang, K Nie, R Lin, L Peng, X Zhou… - European Journal of …, 2023 - Elsevier
Objective Major depressive disorder (MDD) is a debilitating psychiatric disorder which is
common and endangers human physical and mental health. Studies have shown that …

[HTML][HTML] Ion channel dysfunction and neuroinflammation in migraine and depression

E Eren-Koçak, T Dalkara - Frontiers in Pharmacology, 2021 - frontiersin.org
Migraine and major depression are debilitating disorders with high lifetime prevalence rates.
Interestingly these disorders are highly comorbid and show significant heritability …

[HTML][HTML] Flavonols in action: Targeting oxidative stress and neuroinflammation in major depressive disorder

M Jazvinšćak Jembrek, N Oršolić, D Karlović… - International journal of …, 2023 - mdpi.com
Major depressive disorder is one of the most common mental illnesses that highly impairs
quality of life. Pharmacological interventions are mainly focused on altered monoamine …

Polydatin prevents neuroinflammation and relieves depression via regulating Sirt1/HMGB1/NF-κB signaling in mice

H Bian, L Xiao, L Liang, Y Xie, H Wang, M Slevin… - Neurotoxicity …, 2022 - Springer
Depression is a prevalent psychiatric disorder with a significant health impact and economic
burden worldwide. Unfortunately, the exact pathogenesis of depression is not well …