[HTML][HTML] Alzheimer's disease as a viral disease: Revisiting the infectious hypothesis
Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people.
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …
[HTML][HTML] Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories
S Hassamal - Frontiers in psychiatry, 2023 - frontiersin.org
In a subset of patients, chronic exposure to stress is an etiological risk factor for
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …
EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling
Aims Erythropoietin (EPO) is a glycoprotein cytokine that exerts therapeutic potential on
neurological disorders by promoting neurogenesis and angiogenesis. However, its role as …
neurological disorders by promoting neurogenesis and angiogenesis. However, its role as …
Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents
T Mokhtari - Phytotherapy Research, 2022 - Wiley Online Library
Major depressive disorder (MDD) is a life‐threatening disease that presents several
characteristics. The pathogenesis of depression still remains poorly understood. Moreover …
characteristics. The pathogenesis of depression still remains poorly understood. Moreover …
[HTML][HTML] Microglial responses to stress-induced depression: causes and consequences
R Afridi, K Suk - Cells, 2023 - mdpi.com
Chronic stress is a major risk factor for various psychiatric diseases, including depression; it
triggers various cellular and structural changes, resulting in the alteration of neurocircuitry …
triggers various cellular and structural changes, resulting in the alteration of neurocircuitry …
Canagliflozin attenuates chronic unpredictable mild stress induced neuroinflammation via modulating AMPK/mTOR autophagic signaling
LH Khedr, RM Eladawy, NN Nassar, MAE Saad - Neuropharmacology, 2023 - Elsevier
Although vast progress has been made to understand the pathogenesis of depression,
existing antidepressant remedies, with several adverse effects, are not fully adequate …
existing antidepressant remedies, with several adverse effects, are not fully adequate …
Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model
H Cao, D Yang, K Nie, R Lin, L Peng, X Zhou… - European Journal of …, 2023 - Elsevier
Objective Major depressive disorder (MDD) is a debilitating psychiatric disorder which is
common and endangers human physical and mental health. Studies have shown that …
common and endangers human physical and mental health. Studies have shown that …
[HTML][HTML] Ion channel dysfunction and neuroinflammation in migraine and depression
E Eren-Koçak, T Dalkara - Frontiers in Pharmacology, 2021 - frontiersin.org
Migraine and major depression are debilitating disorders with high lifetime prevalence rates.
Interestingly these disorders are highly comorbid and show significant heritability …
Interestingly these disorders are highly comorbid and show significant heritability …
[HTML][HTML] Flavonols in action: Targeting oxidative stress and neuroinflammation in major depressive disorder
Major depressive disorder is one of the most common mental illnesses that highly impairs
quality of life. Pharmacological interventions are mainly focused on altered monoamine …
quality of life. Pharmacological interventions are mainly focused on altered monoamine …
Polydatin prevents neuroinflammation and relieves depression via regulating Sirt1/HMGB1/NF-κB signaling in mice
H Bian, L Xiao, L Liang, Y Xie, H Wang, M Slevin… - Neurotoxicity …, 2022 - Springer
Depression is a prevalent psychiatric disorder with a significant health impact and economic
burden worldwide. Unfortunately, the exact pathogenesis of depression is not well …
burden worldwide. Unfortunately, the exact pathogenesis of depression is not well …