Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to
injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem …

Epithelial surfaces line the body and provide a crucial interface between the body and the
external environment. Tissue-resident epithelial γδ T cells represent a major T cell …

INTRODUCTION Tissue stem cells respond to and integrate environmental cues to
determine their fate and function. Injury induces radical changes in the microenvironment …

Age-associated chronic inflammation (inflammageing) is a central hallmark of ageing, but its
influence on specific cells remains largely unknown. Fibroblasts are present in most tissues …

Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We
explored how the microbiota was sensed by the immune system and the defining properties …

Tissues have a natural capacity to replace dying cells and to heal wounds. This ability
resides in resident stem cells, which self-renew, preserve, and repair their tissue during …

The microbiota plays a fundamental role in regulating host immunity. However, the
processes involved in the initiation and regulation of immunity to the microbiota remain …

Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting
in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue …

INTRODUCTION Barrier tissues are constitutive targets of environmental stressors and are
home to a highly diverse microbiota. When the immune system encounters these …

BACKGROUND In addition to providing antimicrobial immunity, the immune system governs
numerous aspects of host physiology, in part through the coordinated action of tissue …