Dendritic epidermal T cells (DETC) are a group of immune cells expressing canonical γδ
TCR in the murine epidermis. Similar to γδ T cells in the human epidermis, DETC serve an …

Wound healing is a very complex process, where variety of different pathways is activated,
depending on the phase of healing. Improper or interrupted healing might result in …

An orchestrated wound healing program drives skin repair via collective epidermal cell
proliferation and migration. However, the molecular determinants of the tissue …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

An effective healing response is critical to promote and ensure healthy aging. Major
discoveries in both fields—repair and aging—have led to a better understanding of the …

Aging is generally characterized as a gradual increase in tissue damage, which is
associated with senescence and chronic systemic inflammation and is evident in a variety of …

Aging is associated with reduced tissue remodeling efficiency and increased fibrosis,
characterized by excess collagen accumulation and altered matrix degradation. Ovulation …

Chronic wounds develop when the orderly process of cutaneous wound healing is delayed
or disrupted. Development of a chronic wound is associated with significant morbidity and …

Mitochondria are intracellular organelles that play a critical role in numerous cellular
processes including the regulation of metabolism, cellular stress response, and cell fate …

Skin regenerative capacity declines with age, but the underlying mechanisms are largely
unknown. Here we demonstrate a functional link between epidermal growth factor receptor …