Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle
Y Zhuang, S Jiang, X Deng, A Lao, X Hua, Y Xie… - Science …, 2024 - science.org
Aging skin, vulnerable to age-related defects, is poor in wound repair. Metabolic regulation
in accumulated senescent cells (SnCs) with aging is essential for tissue homeostasis, and …
in accumulated senescent cells (SnCs) with aging is essential for tissue homeostasis, and …
The biological processes during wound healing
F Yang, X Bai, X Dai, Y Li - Regenerative medicine, 2021 - Taylor & Francis
Numerous individuals suffer from impaired wound healing, such as chronic ulcers, severe
burns and immune disorders, resulting in both public health and economic burdens. Skin is …
burns and immune disorders, resulting in both public health and economic burdens. Skin is …
Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin
Stem cell loss causes tissue deterioration associated with aging. The accumulation of
genomic and oxidative stress-induced DNA damage is an intrinsic cue for stem cell loss,; …
genomic and oxidative stress-induced DNA damage is an intrinsic cue for stem cell loss,; …
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
Regulatory T (Treg) cells, expressing CD25 (interleukin-2 receptor α chain) and Foxp3
transcription factor, maintain immunological self-tolerance and suppress various immune …
transcription factor, maintain immunological self-tolerance and suppress various immune …
Deciphering the regulatory landscape of fetal and adult γδ T‐cell development at single‐cell resolution
Abstract γδ T cells with distinct properties develop in the embryonic and adult thymus and
have been identified as critical players in a broad range of infections, antitumor surveillance …
have been identified as critical players in a broad range of infections, antitumor surveillance …
T lymphocytes attenuate dermal scarring by regulating inflammation, neovascularization, and extracellular matrix remodeling
Objective: While tissue injury and repair are known to involve adaptive immunity, the profile
of lymphocytes involved and their contribution to dermal scarring remain unclear. We …
of lymphocytes involved and their contribution to dermal scarring remain unclear. We …
Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells
The cutaneous wound-healing program is a product of a complex interplay among diverse
cell types within the skin. One fundamental process that is mediated by these reciprocal …
cell types within the skin. One fundamental process that is mediated by these reciprocal …
Aging suppresses skin-derived circulating SDF1 to promote full-thickness tissue regeneration
Physicians have observed that surgical wounds in the elderly heal with thinner scars than
wounds in young patients. Understanding this phenomenon may reveal strategies for …
wounds in young patients. Understanding this phenomenon may reveal strategies for …
[HTML][HTML] Universal recording of cell–cell contacts in vivo for interaction-based transcriptomics
S Nakandakari-Higa, MCC Canesso, S Walker… - BioRxiv, 2023 - ncbi.nlm.nih.gov
Cellular interactions are essential for tissue organization and functionality. In particular,
immune cells rely on direct and usually transient interactions with other immune and non …
immune cells rely on direct and usually transient interactions with other immune and non …
Reproducible strategy for excisional skin-wound-healing studies in mice
M Yampolsky, I Bachelet, Y Fuchs - Nature Protocols, 2024 - nature.com
Wound healing is a complex physiological process involving various cell types and
signaling pathways. The capability to observe the dynamics of wound repair offers valuable …
signaling pathways. The capability to observe the dynamics of wound repair offers valuable …