[HTML][HTML] Central nervous system targets: glial cell mechanisms in chronic pain

CR Donnelly, AS Andriessen, G Chen, K Wang… - …, 2020 - Elsevier
Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

Use of cannabidiol (CBD) for the treatment of chronic pain

I Urits, K Gress, K Charipova, K Habib, D Lee… - Best Practice & …, 2020 - Elsevier
Chronic pain can be recurrent or constant pain that lasts for longer than 3 months and can
result in disability, suffering, and a physical disturbance. Related to the complex nature of …

The effect of probiotic supplementation on the clinical and Para-clinical findings of multiple sclerosis: a randomized clinical trial

KM Asghari, N Dolatkhah, H Ayromlou, F Mirnasiri… - Scientific Reports, 2023 - nature.com
Multiple Sclerosis (MS) is a chronic demyelination disease of the central nervous system
(CNS). The gut-brain axis involves communication between the nervous, endocrine, and …

Inflammation in pathogenesis of chronic pain: Foe and friend

XX Fang, MN Zhai, M Zhu, C He, H Wang… - Molecular …, 2023 - journals.sagepub.com
Chronic pain is a refractory health disease worldwide causing an enormous economic
burden on individuals and society. Accumulating evidence suggests that inflammation in the …

[HTML][HTML] Neuropathic pain in neurologic disorders: a narrative review

DD Mitsikostas, E Moka, E Orrillo, C Aurilio… - Cureus, 2022 - ncbi.nlm.nih.gov
Neuropathic pain is defined as a painful condition caused by neurological lesions or
diseases. Sometimes, neurological disorders may also be associated with neuropathic pain …

Effectiveness of non-pharmacological rehabilitation interventions in pain management in patients with multiple sclerosis: Systematic review and meta-analysis

H Hadoush, A Alawneh, M Kassab… - …, 2022 - content.iospress.com
BACKGROUND: Multiple sclerosis (MS) is a progressive inflammatory and autoimmune
neurological disease caused by inflammation and demyelination of the central nervous …

The epidemiology of primary headaches in patients with multiple sclerosis

L Wang, J Zhang, ZR Deng, MD Zu… - Brain and Behavior, 2021 - Wiley Online Library
Objective Recent studies have shown a pathophysiologic link between headache and
multiple sclerosis (MS), but the prevalence of primary headaches among patients with MS …

Characterizing cannabis use in a sample of adults with multiple sclerosis and chronic pain: An observational study

K Link, LM Knowles, KN Alschuler, DM Ehde - Multiple Sclerosis and …, 2023 - Elsevier
Background Although cannabis has become an increasingly common method for pain
management among people with multiple sclerosis (PwMS), there is a dearth of knowledge …

Endoplasmic reticulum stress in the dorsal root ganglia regulates large‐conductance potassium channels and contributes to pain in a model of multiple sclerosis

MS Yousuf, S Samtleben, SM Lamothe… - The FASEB …, 2020 - Wiley Online Library
Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment
options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) …

Dysregulation of sphingolipid metabolism in pain

J Wang, G Zheng, L Wang, L Meng, J Ren… - Frontiers in …, 2024 - frontiersin.org
Pain is a clinical condition that is currently of great concern and is often caused by tissue or
nerve damage or occurs as a concomitant symptom of a variety of diseases such as cancer …