Altered metabolism and deregulated cellular energetics are now considered a hallmark of
all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-
acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein …

Unlike the complex glycans decorating the cell surface, the O-linked β-N-acetyl glucosamine
(O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is …

Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for
energy production and the synthesis of macromolecules, including proteins, lipids, and …

Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

The Hippo pathway is crucial in organ size control and tissue homeostasis, with
deregulation leading to cancer. An extracellular nutrition signal, such as glucose, regulates …

Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous
glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis …

O-GlcNAcylation, which is a nutrient-sensitive sugar modification, participates in the
epigenetic regulation of gene expression. The enzymes involved in O-linked β-dN …