Nano-drug delivery system targeting tumor microenvironment: a prospective strategy for melanoma treatment

M Xu, S Li - Cancer Letters, 2023 - Elsevier
Melanoma, the most aggressive form of cutaneous malignancy arising from melanocytes, is
frequently characterized by metastasis. Despite considerable progress in melanoma …

An autocatalytic multicomponent DNAzyme nanomachine for tumor-specific photothermal therapy sensitization in pancreatic cancer

J Yan, X Ma, D Liang, M Ran, D Zheng, X Chen… - Nature …, 2023 - nature.com
Multicomponent deoxyribozymes (MNAzymes) have great potential in gene therapy, but
their ability to recognize disease tissue and further achieve synergistic gene regulation has …

Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy

K Wang, X Zhang, H Ye, X Wang, Z Fan, Q Lu… - Nature …, 2023 - nature.com
Abstract Cytokine therapy, involving interleukin-15 (IL-15), is a promising strategy for cancer
immunotherapy. However, clinical application has been limited due to severe toxicity and …

Bioorthogonal Guided Activation of cGAS‐STING by AIE Photosensitizer Nanoparticles for Targeted Tumor Therapy and Imaging

M Cui, D Tang, B Wang, H Zhang, G Liang… - Advanced …, 2023 - Wiley Online Library
Photodynamic therapy (PDT) and photothermal therapy (PTT) leverage reactive oxygen
species (ROS) and control local hyperthermia by photosensitizer to perturb intracellular …

H2S-Reactivating Antitumor Immune Response after Microwave Thermal Therapy for Long-Term Tumor Suppression

S Li, F Xu, X Ren, L Tan, C Fu, Q Wu, Z Chen, J Ren… - ACS …, 2023 - ACS Publications
Microwave thermal therapy (MWTT) is one of the most potent ablative treatments known,
with advantages like deep penetration, minimal invasion, repeatable operation, and low …

An NIR‐II Excitable AIE Small Molecule with Multimodal Phototheranostic Features for Orthotopic Breast Cancer Treatment

S Song, Y Zhao, M Kang, F Zhang, Q Wu… - Advanced …, 2024 - Wiley Online Library
One‐for‐all phototheranostics, referring to a single component simultaneously exhibiting
multiple optical imaging and therapeutic modalities, has attracted significant attention due to …

In vivo visualization of tumor-associated macrophages re-education by photoacoustic/fluorescence dual-modal imaging with a metal-organic frames-based caspase-1 …

Z Fan, X Jiang, T Sun, F Zeng, G Huang, C Liang… - Journal of Colloid and …, 2024 - Elsevier
Tumor-associated macrophages (TAMs) are vital in the tumor microenvironment,
contributing to immunosuppression and therapy tolerance. Despite their importance, the …

A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-II Photo-Immunotherapy of Metastatic Tumor

Y Gao, Y Liu, X Li, H Wang, Y Yang, Y Luo, Y Wan… - Nano-Micro Letters, 2024 - Springer
Massive efforts have been concentrated on the advance of eminent near-infrared (NIR)
photothermal materials (PTMs) in the NIR-II window (1000–1700 nm), especially organic …

Self-Adjuvanting Polyguanidine Nanovaccines for Cancer Immunotherapy

X Zhang, K Wang, Z Zhao, X Shan, Y Wang, Z Feng… - ACS …, 2024 - ACS Publications
Tapping into the innate immune system's power, nanovaccines can induce tumor-specific
immune responses, which is a promising strategy in cancer immunotherapy. However …

A biomimetic cuproptosis amplifier for targeted NIR-II fluorescence/photoacoustic imaging-guided synergistic NIR-II photothermal immunotherapy

Y Dai, L Zhu, X Li, F Zhang, K Chen, G Jiao, Y Liu… - Biomaterials, 2024 - Elsevier
The therapeutic efficacy of cuproptosis combined with phototheranostics is still hindered by
easy copper efflux, nonspecific accumulation and limited light penetration depth. Here, a …