Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth
muscle (ASM) functions including contraction, growth, and" synthetic" functions that …

Although pivotal in regulating bronchomotor tone in asthma, airway smooth muscle (ASM)
also modulates airway inflammation and undergoes hypertrophy and hyperplasia …

β2-Adrenergic receptors (β2ARs) are important regulators of airway smooth muscle tone,
and β-sympathomimetic drugs are the most widely used agents in asthma therapy and are …

Endothelin is a small peptide that is a potent bronchoconstrictor, mitogen for airway smooth
muscle (ASM), and is believed to be involved in the pathogenesis of asthma. To understand …

Asthma as well as bronchiolitis obliterans and chronic bronchitis are chronic lung diseases
characterized by airflow obstruction and airway inflammation. Although asthma typically …

Asthma is a disease of airway inflammation and bronchoconstriction that results in airway
smooth-muscle cell hypertrophy and hyperplasia. The underlying mechanisms that induce …

The increase in the amount of airway smooth muscle in the bronchial wall associated with
asthma is partly due to hyperplasia. It is therefore important to determine which factors …

In a variety of diseases including asthma, inflammation causes microvascular leakage and
activates thrombin. In addition to cleaving fibrinogen to fibrin, thrombin may have other …

Previously we reported that the G protein‐coupled receptor (GPCR) agonist thrombin
potentiated the mitogenic effect of epidermal growth factor (EGF) on human airway smooth …

Protein kinase C (PKC) is implicated in the regulation of smooth muscle contractility and
growth. We have previously described the pattern of isoform expression of PKC in canine …