[HTML][HTML] Cancer prevention and therapy through the modulation of the tumor microenvironment
SC Casey, A Amedei, K Aquilano, AS Azmi… - Seminars in cancer …, 2015 - Elsevier
Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …
[HTML][HTML] Relationship between VEGF family members, their receptors and cell death in the neoplastic transformation of colorectal cancer
D Dakowicz, M Zajkowska, B Mroczko - International journal of molecular …, 2022 - mdpi.com
Colorectal cancer (CRC) is the second most common cause of cancer death in the world.
Both modifiable and nonmodifiable risk factors play a significant role in the pathogenesis of …
Both modifiable and nonmodifiable risk factors play a significant role in the pathogenesis of …
Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor‐2 inhibitor
C Xie, X Wan, H Quan, M Zheng, L Fu, Y Li… - Cancer …, 2018 - Wiley Online Library
Abrogating tumor angiogenesis by inhibiting vascular endothelial growth factor receptor‐2
(VEGFR 2) has been established as a therapeutic strategy for treating cancer. However …
(VEGFR 2) has been established as a therapeutic strategy for treating cancer. However …
Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer
MS Nafie, ATA Boraei - Bioorganic Chemistry, 2022 - Elsevier
Abstract According to the World Health Organization (WHO) statistics: In 2020, there were
2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore …
2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore …
[HTML][HTML] Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers
The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …
Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …
Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2, 4-dione derivatives targeting VEGFR-2 enzyme
Abstract Novel series of 5-benzylidenethiazolidine-2, 4-dione derivatives 4 ac-8 af were
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …
[HTML][HTML] Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
Incomplete understanding of the metastatic process hinders personalized therapy. Here we
report the most comprehensive whole-genome study of colorectal metastases vs. matched …
report the most comprehensive whole-genome study of colorectal metastases vs. matched …
[HTML][HTML] The mechanisms of ferroptosis under hypoxia
X Gao, W Hu, D Qian, X Bai, H He, L Li… - Cellular and Molecular …, 2023 - Springer
Ferroptosis is a new form of programmed cell death, which is characterized by the iron-
dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative …
dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative …
[HTML][HTML] Maternal dietary fatty acids and their roles in human placental development
AK Duttaroy, S Basak - Prostaglandins, Leukotrienes and Essential Fatty …, 2020 - Elsevier
Fatty acids are essential for feto-placental growth and development. Maternal fatty acids and
their metabolites are involved in every stage of pregnancy by supporting cell growth and …
their metabolites are involved in every stage of pregnancy by supporting cell growth and …