The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …

Nonalcoholic fatty liver disease (NAFLD) is common in the elderly, in whom it carries a more
substantial burden of hepatic (nonalcoholic steatohepatitis, cirrhosis and hepatocellular …

Background Opioid-induced constipation is common and debilitating. We investigated the
efficacy and safety of naloxegol, an oral, peripherally acting, μ-opioid receptor antagonist, for …

Poorly controlled pain is a global public health issue. The personal, familial and societal
costs are immeasurable. Only a minority of European patients have access to a …

OBJECTIVE The aim of this study was to systematically review the published literature
regarding prevalence, risk factors, incidence, natural history, and the effect on quality of life …

ABSTRACT Objective. This multinational, Internet-based survey was designed to assess the
prevalence, frequency, severity, and impact of opioid-induced bowel dysfunction (OBD) in …

Constipation is a common problem in patients with advanced cancer and a significant
source of major morbidity and distress, which is often under-appreciated [1]. Constipation is …

Objective To formulate timely evidence-based guidelines for the management of opioid-
induced bowel dysfunction. Setting Constipation is a major untoward effect of opioids …

BACKGROUND: Bupivacaine extended-release liposome injection is a novel formulation of
bupivacaine designed to achieve long-acting postoperative analgesia. OBJECTIVE: The aim …

Opioid treatment for postoperative or chronic pain is frequently associated with adverse
effects, the most common being dose-limiting and debilitating bowel dysfunction …