Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of
bile acid (BA) synthesis and enterohepatic circulation. FXR can influence glucose and lipid …

Farnesoid X receptor (FXR), a metabolic nuclear receptor, plays critical roles in the
maintenance of systemic energy homeostasis and the integrity of many organs, including …

Background & Aims Many genetic and environmental factors, including family history, dietary
fat, and inflammation, increase risk for colon cancer development. Peroxisome proliferator …

A hyperactive immune response can be observed in patients with bacterial or viral infection,
which may lead to the overproduction of proinflammatory cytokines, or “cytokine storm”, and …

Farnesoid X receptor (FXR) influences bile acid homeostasis and the progression of various
diseases. While the roles of hepatic and intestinal FXR in enterohepatic transport of bile …

Cholestasis results in blockage of bile flow whether the point of obstruction occurs
extrahepatically or intrahepatically. Bile acids are a primary constituent of bile, and thus one …

Recent studies have investigated the roles of FXR deficiency in the pathogenesis of
alcoholic liver disease (ALD). However, the underlying molecular mechanisms remain …

Loss of FXR, one of bile acid receptors, enlarged livers. Yes‐associated protein 1 (YAP1), a
dominant oncogene, promotes hepatocellular carcinoma (HCC). However, the relationship …

Peroxisome proliferator-activated receptor alpha (PPARα) controls lipid homeostasis
through regulation of lipid transport and catabolism. PPARα activators are clinically used for …

Aims: Acetaminophen (APAP) overdose leads to acute liver injury by inducing hepatic
mitochondrial oxidative stress and inflammation. However, the molecular mechanisms …