Which behavioral test is the most sensitive for detecting cognitive deficits in the 3xTg-AD at
6.5 months of age? The 3xTg-AD mouse model of Alzheimer's disease (AD) has three …

Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of
dementia. Hallmarks of AD are memory impairments and cognitive deficits, but non-cognitive …

The 3xTg-AD mouse has high validity as a model of Alzheimer's disease (AD) because it
develops both amyloid beta plaques and neurofibrillary tangles. Human patients with AD …

Motor deficits are some of the most prevalent non-cognitive symptoms of Alzheimer's
disease (AD) with patients showing impairments in speech, gait and fine motor skills. We …

Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease in which
cognitive decline takes place over a period of several years with a very variable period of …

Visual impairments and retinal abnormalities occur in patients with Alzheimer's disease (AD)
and in mouse models of AD. It is important to know the visual ability of mouse models of AD …

Studies described in this thesis deal with the preventive effects of a neurogenic/neurotropic
peptidergic compound, P021, on neurogenesis and synaptic deficits, neurodegeneration …

Alzheimer's Disease (AD) is a neurodegenerative disease associated with global cognitive
impairment. The cognitive reserve hypothesis posits that individuals with a socially …

Citation: Wagner JM, Sichler ME, Schleicher EM, Franke TN, Irwin C, Löw MJ, Beindorff N,
Bouter C, Bayer TA and Bouter Y (2019) Analysis of Motor Function in the Tg4-42 Mouse …

1.1 Background of Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative
disorder, first presented by the German physician Alois Alzheimer in 1906. In the 4 …