Colorectal cancer commonly metastasizes. The liver is the most frequent site of metastases
and dominates the length of survival for this disease. As surgical and systemic therapies …

Over the last few decade Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the drugs of
choice for treating numerous inflammatory diseases including rheumatoid arthritis. The …

Patients with advanced stage cancers frequently suffer from severe pain as a result of bone
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …

The prevalence and cost of chronic pain is a major physical and mental health care problem
in the United States today. As a result, there has been a recent explosion of research on …

The most common human cancers—lung, breast and prostate—have a great avidity for
bone, leading to painful and untreatable consequences. What makes some cancers, but not …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Cancer pain, especially pain caused by metastasis to bone, is a severe type of pain, and
unless the cause and consequences can be resolved, the pain will become chronic. As …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer. PNI is a process
whereby cancer cells invade the surrounding nerves, thus providing an alternative route for …

Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic
Management | Annals of Internal Medicine Advertisement ACP Online Annals of Internal …