Importance Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis
that started in North America and spread throughout high-income countries. The aim of this …

Background Previous studies have reported an extremely unbalanced global access to
opioid analgesics. We aimed to determine contemporary trends and patterns of opioid …

Osteoarthritis (OA) is a chronic joint disease that represents an increasingly substantial
global burden. Joint pain is the most significant symptom of OA. Unfortunately, current …

Background Opioid analgesics play a key role in pain management but providing access
while mitigating risk of misuse and dependence remains a challenge. Tracking global …

Importance There are known risks of using opioids for extended periods. However, less is
known about the long-term trajectories of opioid use following initiation. Objective To identify …

Cannabis‐based medicinal products (CBMPs) are an emerging therapeutic option in the
management of primary chronic pain, using the role of the endocannabinoid system in …

Highlights•Opioid abuse is increasing globally with adverse impacts on health and
economies.•More people consume opioids when macroeconomic performance …

Background The opioid epidemic in North America has been driven by an increase in the
use and potency of prescription opioids, with ensuing excessive opioid-related deaths …

Background To examine time trends and characteristics of calls related to opioid poisonings
reported to the National Poison Centre and opioid sales in Switzerland. Methods We used …

Objective To identify individual and initial prescription-related factors associated with an
increased risk for opioid-related misuse, poisoning and dependence (MPD) in patients with …