The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

Genes involved in the production of pulmonary surfactant are crucial for the development
and maintenance of healthy lungs. Germline mutations in surfactant-related genes cause a …

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can
inform our understanding of the underlying biological mechanisms that influence adverse …

Abstract Purpose SARS-CoV-2 (COVID-19) has infected more than 7 million people
worldwide in the short time since it emerged in Wuhan, China in December 2019. The aim of …

SARS-CoV-2 started spreading toward the end of 2019 causing COVID-19, a disease that
reached pandemic proportions among the human population within months. The reasons for …

Pulmonary surfactant is a mixture of lipids and proteins, consisting of 90% phospholipid, and
10% protein by weight, found predominantly in pulmonary alveoli of vertebrate lungs. Two …

An incomplete understanding of the molecular mechanisms behind impairment of lung
pathobiology by COVID-19 complicates its clinical management. In this study, we analyzed …

Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape
tissues, influence social interactions, and protect against pathogens and other …

Different families of endogenous lectins use complementary defense strategies against
pathogens. They may recognize non-self glycans typically found on pathogens and/or host …

Inhaled substances, such as consumer products, chemicals at the workplace, and
nanoparticles, can affect the lung function in several ways. In this paper, we explore the …