Metastatic melanoma remained for decades without any effective treatment and was thus
considered as a paradigm of cancer resistance. Recent progress with understanding of the …

The population of elderly individuals with rheumatoid arthritis (RA) is expanding, due mainly
to increasing life expectancy. A variety of theories have been proposed to explain the ageing …

Melanoma cells can enter the process of senescence, but whether they express a secretory
phenotype, as reported for other cells, is undetermined. This is of paramount importance …

Melanoma is the deadliest form of skin cancer, affecting men more frequently and severely
than women. Although recent studies suggest that differences in activity of the androgen …

Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell
survival. Although components of melanoma cytoprotective mechanisms are overexpressed …

Canonical Wnt signaling influences cellular fate and proliferation through inhibition of
Glycogen Synthase Kinase (GSK3) and the subsequent stabilization of its many substrates …

Studies in animals suggest that caffeine administration helps prevent squamous cell skin
cancer development, but there have been limited epidemiologic studies on the association …

Melanoma is an aggressive neoplasm with increasing incidence that is classified by the NCI
as a recalcitrant cancer, ie, a cancer with poor prognosis, lacking progress in diagnosis and …

Malignant melanoma is the most aggressive form of skin cancer and has a very low survival
rate. Over 50% of melanomas harbor various BRAF mutations with the most common being …

Cellular senescence is an endpoint of chemotherapy, and targeted therapies in melanoma
and the senescence-associated secretory phenotype (SASP) can affect tumor growth and …