Cytosolic recognition of microbes and pathogens: inflammasomes in action

JA Hayward, A Mathur, C Ngo… - … and Molecular Biology …, 2018 - Am Soc Microbiol
Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

Innate Immunity to Aspergillus Species

SJ Park, B Mehrad - Clinical microbiology reviews, 2009 - Am Soc Microbiol
All humans are continuously exposed to inhaled Aspergillus conidia, yet healthy hosts clear
the organism without developing disease and without the development of antibody-or cell …

Essential Role for Neutrophils but not Alveolar Macrophages at Early Time Points following Aspergillus fumigatus Infection

MM Mircescu, L Lipuma, N Van Rooijen… - The Journal of …, 2009 - academic.oup.com
Alveolar macrophages and neutrophils mediate innate immune defense against the
opportunistic fungal pathogen Aspergillus fumigatus and are believed to be essential for …

[HTML][HTML] Interactions of Aspergillus fumigatus Conidia with Airway Epithelial Cells: A Critical Review

CA Croft, L Culibrk, MM Moore, SJ Tebbutt - Frontiers in microbiology, 2016 - frontiersin.org
Aspergillus fumigatus is an environmental filamentous fungus that also acts as an
opportunistic pathogen able to cause a variety of symptoms, from an allergic response to a …

[HTML][HTML] The innate immune response to Aspergillus fumigatus

V Balloy, M Chignard - Microbes and infection, 2009 - Elsevier
Despite the development of new treatments, the mortality due to invasive pulmonary
aspergillosis remains above 50%, reaching 95% in certain situations. The battle against …

[HTML][HTML] Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations

S Lara-Reyna, J Holbrook, HH Jarosz-Griffiths… - Cellular and Molecular …, 2020 - Springer
Cystic fibrosis (CF) is one of the most common life-limiting recessive genetic disorders in
Caucasians, caused by mutations in the cystic fibrosis transmembrane conductance …

Antifungal innate immunity: recognition and inflammatory networks

KL Becker, DC Ifrim, J Quintin, MG Netea… - Seminars in …, 2015 - Springer
A large variety of fungi are present in the environment, among which a proportion colonizes
the human body, usually without causing any harm. However, depending on the host …

[HTML][HTML] Interaction of the pathogenic mold Aspergillus fumigatus with lung epithelial cells

N Osherov - Frontiers in microbiology, 2012 - frontiersin.org
Aspergillus fumigatus is an opportunistic environmental mold that can cause severe allergic
responses in atopic individuals and poses a life-threatening risk for severely …

[HTML][HTML] Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease

M Bertuzzi, GE Hayes, UJ Icheoku, N Van Rhijn… - Journal of Fungi, 2018 - mdpi.com
Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as
primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores …

Large‐scale cultivation of the bumblebee gut microbiota reveals an underestimated bacterial species diversity capable of pathogen inhibition

J Praet, A Parmentier… - Environmental …, 2018 - Wiley Online Library
A total of 1940 isolates from gut samples of 60 bumblebees representing Bombus
pascuorum, Bombus terrestris, Bombus lucorum and Bombus lapidarius was collected and …