Early life adversity (ELA) is a risk factor for major depressive disorder (MDD), however the
underlying mechanisms are not well understood. Clinical studies suggest that negative …

The behavioral, biochemical, and physiologic consequences of 6 wk of environmental
enrichment were evaluated in male Long Evans and Sprague–Dawley rats and compared …

Chronic variable stress (CVS) and manipulations of 5-HT-ergic neurotransmission are
increasingly used as animal models of depression. In the present study, CVS for 2 weeks …

Epigenetic modulation of brain-derived neurotrophic factor (BDNF) provides one possible
explanation for the dysfunctions induced by stress, such as psychiatric disorders and …

Stress plays an important role in the development of affective disorders. Women show a
higher prevalence for these disorders then men. The course of a depression is thought to be …

Exposure to chronic stress can affect cognitive processes in a complex manner depending
upon the intensity and duration of the stressors. The current study investigated the effects of …

Chronic pain is a multidimensional experience that not only includes changes in
nociception, but also impairments in emotion and cognitive functions. These last 2 …

The sucrose preference test is a popular test for anhedonia in the chronic unpredictable
stress model of depression. Yet, the test does not always produce consistent results. Long …

The present study was designed to assess the effect of dexamethasone, a synthetic
glucocorticoid receptor agonist, in the sucrose preference test in rats. Rats treated acutely …

Despite the development of valuable new techniques (ie, genetics, neuroimage) for the
study of the neurobiological substrate of psychiatric diseases, there are strong limitations in …