With the gradual demographic shift toward an aging and obese society, an increasing
number of patients are suffering from bone and cartilage injuries. However, conventional …

Background The management of articular cartilage defects presents many clinical
challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation …

Objective Clinical and animal studies have demonstrated the efficacy of mesenchymal stem
cell (MSC) therapies in cartilage repair. As the efficacy of many MSC-based therapies has …

Currently, osteochondral defects frequently cause limited motion and impaired function of
the joint, leading to serious healthcare problems, and it is still very challenging to realize the …

Hyaline cartilage plays a critical role in maintaining joint function and pain. However, the
lack of blood supply, nerves, and lymphatic vessels greatly limited the self-repair and …

We propose a method of preparing a novel cell carrier derived from natural cartilage
extracellular matrix (ECM), designated cartilage ECM-derived particles (CEDPs). Through a …

Abstract Background Chondrogenic progenitor cells (CPCs) have high self-renewal capacity
and chondrogenic potential. Intra-articular delivery of purified mesenchymal stem cells …

Cartilage has rather limited capacities for self-repair and regeneration. To repair complexly
shaped cartilage tissue defects, we propose the application of microtissues fabricated from …

Heterogeneity of mesenchymal stem cells (MSCs) influences the cell therapy outcome and
the application in tissue engineering. Also, the application of subpopulations of MSCs in …

Evidence accumulated that mesenchymal stem cell (MSC) therapy ameliorated osteoarthritis
(OA) via paracrine effect, whereas conditioned medium (CM) of MSCs contains all the …