Targeting carbonic anhydrases for the management of hypoxic metastatic tumors
CT Supuran - Expert Opinion on Therapeutic Patents, 2023 - Taylor & Francis
Introduction Several isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …
are connected with tumorigenesis. Hypoxic tumors overexpress CA IX and XII as a …
pH regulators and their inhibitors in tumor microenvironment
S Liao, G Wu, Z Xie, X Lei, X Yang, S Huang… - European journal of …, 2024 - Elsevier
As an important characteristic of tumor, acidic tumor microenvironment (TME) is closely
related to immune escape, invasion, migration and drug resistance of tumor. The acidity of …
related to immune escape, invasion, migration and drug resistance of tumor. The acidity of …
“Cicada Out of the Shell” Deep Penetration and Blockage of the HSP90 Pathway by ROS‐Responsive Supramolecular Gels to Augment Trimodal Synergistic Therapy
F Li, J Yan, C Wei, Y Zhao, X Tang, L Xu… - Advanced …, 2024 - Wiley Online Library
Deep penetration and downregulation of heat shock protein (HSP) expression in multimodal
synergistic therapy are promising approaches for curing cancer in clinical trials. However …
synergistic therapy are promising approaches for curing cancer in clinical trials. However …
Discovery of a New Class of 1-(4-Sulfamoylbenzoyl) piperidine-4-carboxamides as Human Carbonic Anhydrase Inhibitors
A series of 1-(4-sulfamoylbenzoyl) piperidine-4-carboxamides deriving from substituted
piperazines/benzylamines was designed, synthesized, and tested on human carbonic …
piperazines/benzylamines was designed, synthesized, and tested on human carbonic …
Dynamics of small molecule-enzyme interactions: Novel benzenesulfonamides as multi-target agents endowed with inhibitory effects against some metabolic …
In contemporary medicinal chemistry, employing a singular small molecule to concurrently
multi-target disparate molecular entities is emerging as a potent strategy in the ongoing …
multi-target disparate molecular entities is emerging as a potent strategy in the ongoing …
Chemistry of heterocycles as carbonic anhydrase inhibitors: A pathway to novel research in medicinal chemistry review
Nowadays, the scientific community has focused on dealing with different kinds of diseases
by exploring the chemistry of various heterocycles as novel drugs. In this connection …
by exploring the chemistry of various heterocycles as novel drugs. In this connection …
Current Scenario of Pyridine/Quinoline-Sulfonamide Hybrids with Anticancer Potential (A Review)
GL Dong, YP Feng, JJ Wang, X Sun - Russian Journal of General …, 2024 - Springer
Cancer, which proliferates and spreads uncontrollably due to the accumulation of genetic
and epigenetic factors, is one of the most fatal diseases. Cancer management meets …
and epigenetic factors, is one of the most fatal diseases. Cancer management meets …
Screening campaign and docking investigations in identifying new hit compounds as inhibitors of human carbonic anhydrases expressed in tumour cells
F Ricci, A Angeli, F Mancuso, L De Luca… - …, 2023 - Wiley Online Library
The tumor‐expressed human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII have
been extensively studied to develop anticancer agents targeting solid tumors in combined …
been extensively studied to develop anticancer agents targeting solid tumors in combined …
Design, preparation and structural studies of biologically relevant protein variants of cancer-related Carbonic Anhydrase IX
A Fejfarová - 2024 - dspace.cuni.cz
3 Abstract Carbonic anhydrase IX (CA IX) represents an attractive target for the development
of anticancer drugs as it is overexpressed in various types of solid tumors. By its catalytic …
of anticancer drugs as it is overexpressed in various types of solid tumors. By its catalytic …