An increasing number of industrial bioprocesses capitalize on living cells by using them as
cell factories that convert sugars into chemicals. These processes range from the production …

Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

Industrial biotechnology encompasses a large area of multi-scale and multi-disciplinary
research activities. With the recent megatrend of digitalization sweeping across all …

The Handbook of Fungal Biotechnology offers the newest developments from the frontiers of
fungal biochemical and molecular processes and industrial and semi-industrial applications …

In this work we present a general (mono and multiobjective) optimization framework for the
technological improvement of biochemical systems. The starting point of the method is a …

For the first time, kinetic information from the literature was collected and used to construct
integrative dynamical mathematical models of sphingolipid metabolism. One model was …

The increasing commercial demand for L-carnitine has led to a multiplication of efforts to
improve its production with bacteria. The use of different cell environments, such as growing …

With extraordinary clarity, the Systems Biology: Principles, Methods, and Concepts focuses
on the technical practical aspects of modeling complex or organic general systems. It also …

There is a renewed interest in obtaining a systemic understanding of metabolism, gene
expression and signal transduction processes, driven by the recent research focus on …

Background Optimization methods allow designing changes in a system so that specific
goals are attained. These techniques are fundamental for metabolic engineering. However …