Nuclear receptors comprise a class of intracellular transcription factors whose major role is
to act as sensors of various stimuli and to convert the external signal into a transcriptional …

Background Genomic alterations in DNA damage response (DDR) genes are common in
metastatic castration-resistant prostate cancer (mCRPC). Understanding how these genomic …

Over the past decade, the detection and analysis of liquid biopsy biomarkers such as
circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have advanced …

Comprehensive cancer genome studies have revealed genetically-defined subtypes of
prostate cancer with distinct truncal driver mutations. Because prostate cancer has been …

ABSTRACT Introduction: Prostate cancer (PCa) is one of the most common malignancies in
men and a major cause of cancer deaths among men worldwide. Prostate specific antigen …

In recent years, new therapeutic options have become available for prostate cancer (PC)
patients, generating an urgent need for better biomarkers to guide the choice of therapy and …

Objective By virtue of largely disparate clinical outcomes of prostate cancer (PCA), there is a
pressing need to search for useful biomarkers for PCA prognosis. Cell-free DNA (cfDNA) is a …

Prostate cancer is one of the most frequent cancers in men and is a common cause of
cancer-related death. Despite significant progress in the diagnosis and treatment of this …

The therapeutic landscape of castration-resistant prostate cancer (CRPC) has rapidly
expanded. There is a need to develop noninvasive biomarkers to guide treatment. We …

We report a new mechanism of androgen receptor (AR) mRNA regulation and cytoprotection
in response to AR pathway inhibition (ARPI) stress in prostate cancer (PCA). AR mRNA …