Herb-drug interactions and their impact on pharmacokinetics: an update

W Cheng, K Xia, S Wu, Y Li - Current Drug Metabolism, 2023 - ingentaconnect.com
Herb medicine has a long history of application and is still used worldwide. With the
development of complementary and alternative medicine, the interaction between herb and …

Aspalathin: a rare dietary dihydrochalcone from Aspalathus linearis (rooibos tea)

SK Chaudhary, M Sandasi, F Makolo… - Phytochemistry …, 2021 - Springer
Abstract Aspalathin (2′, 3, 4, 4′, 6′-pentahydroxy-3′-C-β-D-
glucopyranosyldihydrochalcone) is a natural C-linked glucosyl dihydrochalcone present in …

Estrone-conjugated PEGylated liposome Co-loaded paclitaxel and carboplatin improve anti-tumor efficacy in ovarian cancer and reduce acute toxicity of chemo-drugs

H Tang, Y Xie, M Zhu, J Jia, R Liu, Y Shen… - International Journal …, 2022 - Taylor & Francis
Purpose Ovarian cancer is the most lethal gynecologic malignancy. The combination of
paclitaxel (PTX) and carboplatin (CBP) is the first-line remedy for clinical ovarian cancer …

[HTML][HTML] A novel estrogen-targeted PEGylated liposome co-delivery oxaliplatin and paclitaxel for the treatment of ovarian cancer

Y Xie, Z Ren, H Chen, H Tang, M Zhu, Z Lv… - Biomedicine & …, 2023 - Elsevier
Ovarian cancer is the second cause of death among gynecological malignancies. In this
study, we designed a novel estrogen-targeted PEGylated liposome loaded with oxaliplatin …

Differential cytotoxicity of rooibos and green tea extracts against primary rat hepatocytes and human liver and colon cancer cells–causal role of major flavonoids

S Samodien, M Kock, E Joubert… - Nutrition and …, 2021 - Taylor & Francis
Differential anti-proliferative and pro-apoptotic effects of aqueous extracts of green rooibos
(Rg; Aspalathus linearis) and green tea (GT; Camellia sinensis) and an aspalathin-enriched …

[HTML][HTML] Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice

O Patel, CJF Muller, E Joubert, B Rosenkranz, J Louw… - PloS one, 2021 - journals.plos.org
Oral therapeutics used to treat type 2 diabetes and cardiovascular disease often fail to
prevent the progression of disease and their comorbidities. Rooibos (Aspalathus linearis) …

Research progress of herbal medicines on drug metabolizing enzymes: consideration based on toxicology

S Wang, W Li, J Yang, Z Yang, C Yang… - Current Drug …, 2020 - ingentaconnect.com
The clinical application of herbal medicines is increasing, but there is still a lack of
comprehensive safety data and in-depth research into mechanisms of action. The …

[HTML][HTML] Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD

K Gabuza, TI Mabuda, O Patel, N Khuboni… - Plos one, 2024 - journals.plos.org
Background Currently, it is acknowledged that vitamin E, insulin sensitizers and anti-diabetic
drugs are used to manage non-alcoholic fatty liver disease (NAFLD), however, these …

[HTML][HTML] Translation of preclinical ethnomedicine data in LMICs: the example of rooibos

L Pretorius, C Smith - Frontiers in Pharmacology, 2023 - frontiersin.org
All disease, but especially non-communicable diseases, are related to dysfunction of one or
more regulatory systems. In developing countries, long-term management of patients with …

[HTML][HTML] Effects of Catha edulis (Khat) on the Pharmacokinetics of Metformin in Diabetic Rats Using UPLC/MS/MS Analysis and Its Impact on Hepatic CYP450 …

AS Alqahtani, MK Parvez, AM Alqahtani, OI Fantoukh… - Separations, 2023 - mdpi.com
Catha edulis Forsk., commonly known as Khat, is a stimulant plant that is chewed in the
Horn of Africa and the southern regions of the Arabian Peninsula. It is often used alongside …