Investigating polyphenol nanoformulations for therapeutic targets against diabetes mellitus

F Islam, JF Khadija, MR Islam, S Shohag… - Evidence‐Based …, 2022 - Wiley Online Library
Diabetes mellitus (DM) is a fatal metabolic disorder, and its prevalence has escalated in
recent decades to a greater extent. Since the incidence and severity of the disease are …

Anti-obesity properties and mechanism of action of flavonoids: A review

AKS Oliveira, AM de Oliveira e Silva… - Critical Reviews in …, 2022 - Taylor & Francis
Obesity is a major public health problem, and there is increasing scientific interest in its
mechanisms, as well as a search for new compounds with antioxidant and anti-inflammatory …

Moderate aerobic exercise training prevents the augmented hepatic glucocorticoid response induced by high-fat diet in mice

J Dassonvalle, F Díaz-Castro… - International journal of …, 2020 - mdpi.com
Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is
associated with the development of obesity and metabolic syndrome. However, it is not …

[HTML][HTML] Puerarin suppresses the hepatic gluconeogenesis via activation of PI3K/Akt signaling pathway in diabetic rats and HepG2 cells

Y Liu, Y Qiu, Q Chen, X Han, M Cai, L Hao - Biomedicine & …, 2021 - Elsevier
Pueraria, a Chinese herbal medicine, plays an important role in many classic prescriptions
for the treatment of diabetes. Puerarin is the main component of pueraria. The current in vivo …

Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high‐fat diet‐fed mice

A Bahramzadeh, S Samavarchi Tehrani… - Phytotherapy …, 2024 - Wiley Online Library
Lipid accumulation, inflammation, and oxidative stress are the most important causes of
muscle insulin resistance. The aim of this study was to investigate the single and combined …

Role of MAPK/NF-κB pathway in cardioprotective effect of Morin in isoproterenol induced myocardial injury in rats

VK Verma, S Malik, SP Narayanan, E Mutneja… - Molecular biology …, 2019 - Springer
Oxidative stress plays a major role in myocardial injury. Morin, a bioflavonoid has known to
possess various biological activities in previous studies. Hence, this study evaluated the …

Neuroprotective effect of morin hydrate against attention-deficit/hyperactivity disorder (ADHD) induced by MSG and/or protein malnutrition in rat pups: Effect on …

HA Salem, N Elsherbiny, S Alzahrani, HM Alshareef… - Pharmaceuticals, 2022 - mdpi.com
Monosodium glutamate (MSG) is one of the most widely used food additives. However, it
has been linked to protein malnutrition (PM) and various forms of toxicities such as …

The combination of metformin with morin alleviates hepatic steatosis via modulating hepatic lipid metabolism, hepatic inflammation, brown adipose tissue …

SS Tehrani, G Goodarzi, G Panahi, F Zamani-Garmsiri… - Life Sciences, 2023 - Elsevier
Aim The valuable effects of metformin (MET) and morin (MOR) in the improvement of NAFLD
have been proposed, nevertheless, their combination impacts were not investigated so far …

Ameliorating Effect of the Total Flavonoids of Morus nigra L. on Prediabetic Mice Based on Regulation of Inflammation and Insulin Sensitization

X Ren, Y Sun, Q Guo, H Liu, H Jiang, X He… - Journal of Agricultural …, 2022 - ACS Publications
Prediabetes is a critical stage characterized by insulin resistance. Morus nigra L., an edible
plant, is widely used in food and nutritive supplements and exhibits various pharmacological …

Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice

X Ren, Q Guo, H Jiang, X Han, X He, H Liu, Z Xiu… - Phytomedicine, 2023 - Elsevier
Background Prediabetes, a stage characterized by chronic inflammation, obesity and insulin
resistance. Morin and 1-deoxynojirimycin (DNJ) are natural flavonoids and alkaloids …