Oxysterols are present in human atherosclerotic plaque and are suggested to play an active
role in plaque development. Moreover, the oxysterol: cholesterol ratio in plaque is much …

Serine hydrolases (SHs) consist of> 200 enzymes in humans characterized by the presence
of an active site serine that is used for the hydrolysis of substrates. The membership of this …

Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of
hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as …

Hormone-sensitive lipase (HSL) is known to mediate the hydrolysis not only of triacylglycerol
stored in adipose tissue but also of cholesterol esters in the adrenals, ovaries, testes, and …

Hormone-sensitive lipase (HSL) was initially characterized as the hormonally regulated
neutral lipase activity responsible for the breakdown of triacylglycerols into fatty acids in …

Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major
determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a …

Although described initially as an intracellular adipocyte-specific triacylglycerol lipase, it is
now clear that HSL (hormone-sensitive lipase) is expressed in multiple tissues and plays a …

Objective: To directly ascertain the physiological roles in adipocytes of hormone‐sensitive
lipase (HSL; EC 3.1. 1.3), a multifunctional hydrolase that can mediate triacylglycerol …

Accumulation of cholesteryl esters (CE) stored as cytoplasmic lipid droplets is the main
characteristic of macrophage foam cells that are central to the development of …

Rationale: Hydrolysis of intracellular cholesterol ester (CE) is the key step in the reverse
cholesterol transport in macrophage foam cells. We have recently shown that neutral …