Synergistic detoxification efficiency and mechanism of triclocarban degradation by a bacterial consortium in the liver-gut-microbiota axis of zebrafish (Danio rerio)
M Sang, S Liu, H Yan, B Zhang, S Chen, B Wu… - Journal of Hazardous …, 2024 - Elsevier
Triclocarban (TCC), an emerging organic contaminant, poses a potential threat to human
health with long-term exposure. Here, Rhodococcus rhodochrous BX2 and Pseudomonas …
health with long-term exposure. Here, Rhodococcus rhodochrous BX2 and Pseudomonas …
[HTML][HTML] The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway
Z Li, Q Fan, M Chen, Y Dong, F Li, M Wang… - Journal of …, 2023 - Elsevier
Polyphyllin I (PPI) and polyphyllin II (PII) are the main active substances in the Paris
polyphylla. However, liver toxicity of these compounds has impeded their clinical application …
polyphylla. However, liver toxicity of these compounds has impeded their clinical application …
[HTML][HTML] Metabolic characteristics of evodiamine were associated with its hepatotoxicity via PPAR/PI3K/AKT/NF-кB/tight junction pathway-mediated apoptosis in …
Q Fan, R Liang, M Chen, Z Li, X Tao, H Ren… - Ecotoxicology and …, 2024 - Elsevier
Evodiae Fructus (EF), an herbal medicine, possesses remarkable anti-inflammatory and
analgesic properties. It exhibits insecticidal activity as a potent insecticide candidate …
analgesic properties. It exhibits insecticidal activity as a potent insecticide candidate …
Emodin-8-O-β-D-glucopyranoside-induced hepatotoxicity and gender differences in zebrafish as revealed by integration of metabolomics and transcriptomics
T Han, W Xu, X Wang, J Gao, S Zhang, L Yang… - Phytomedicine, 2024 - Elsevier
Abstract Background Emodin-8-O-β-D-glucopyranoside (Em8G) is an active ingredient of
traditional Chinese medicine Rhei Radix et Rhizoma and Polygonum multiflorum Thunb …
traditional Chinese medicine Rhei Radix et Rhizoma and Polygonum multiflorum Thunb …
Investigation of the applicability of the zebrafish model for the evaluation of aristolochic acid-related nephrotoxicity
C Meilin, Z Chongjun, LI Zhiqi, FAN Qiqi, LU Shan… - Phytomedicine, 2023 - Elsevier
Background The risk of compounds/drugs, including aristolochic acid-induced nephrotoxicity
remains high and is a significant public health concern. Therefore, it is particularly important …
remains high and is a significant public health concern. Therefore, it is particularly important …
[PDF][PDF] 基于网络药理学和斑马鱼模型探究复方益肝灵对非酒精性脂肪肝的保护作用及机制
郭思敏， 陈林珍， 陈美琳， 李芝奇… - 中国药学 …, 2023 - journal11.magtechjournal.com
目的基于斑马鱼模型及网络药理学技术研究复方益肝灵对非酒精性脂肪肝的保护作用及机制.
方法采用硫代乙酰胺诱导斑马鱼建立非酒精性脂肪肝动物模型, 以斑马鱼肝脏表型 …
方法采用硫代乙酰胺诱导斑马鱼建立非酒精性脂肪肝动物模型, 以斑马鱼肝脏表型 …